Management and outcome in patients with Klatskin-mimicking lesions of the biliary tree. Academic Article uri icon

Overview

abstract

  • The preoperative and even intraoperative differentiation between benign and malignant strictures at the hepatic hilum remains difficult. The aim of this study was to assess clinical, radiologic, intraoperative, and histopathologic findings; surgical treatment; and outcome of patients with Klatskin mimicking benign lesions. Of 49 consecutive patients who were operated on the initial preoperative radiologic diagnosis of hilar adenocarcinoma (Klatskin tumor), 7 (14%) had benign conditions after final histopathologic diagnosis. Pretreatment work-up, therapy, and outcome of these patients were analyzed. Based on preoperative clinical symptoms, imaging assessment, and CA19-9 values, all seven patients were classified as having malignant neoplasms. At laparotomy, the tumors of six patients were judged to be malignant. Five patients underwent hilar resection and concomitant liver resection, and two patients underwent hilar resection alone. There were no operative deaths. The definitive histopathologic examination showed severe cholangitis with extensive periductal fibrosis in all patients. After a median follow-up of 32 months, all patients are well. Clinical presentation and imaging assessment were similar for Klatskin tumors and benign fibrosing disease; therefore, an aggressive resectional approach is justified in any patient with suspicious obstruction of the liver hilum.

publication date

  • January 1, 2006

Research

keywords

  • Bile Duct Neoplasms
  • Cholecystectomy
  • Hepatectomy
  • Hepatic Duct, Common
  • Klatskin Tumor

Identity

Scopus Document Identifier

  • 33748463389

Digital Object Identifier (DOI)

  • 10.1016/j.gassur.2006.04.003

PubMed ID

  • 16966034

Additional Document Info

volume

  • 10

issue

  • 8