Pharmacogenomics of colorectal cancer prevention and treatment. Review uri icon

Overview

abstract

  • Pharmacogenomic tools are beginning to emerge that will provide guidance in the treatment and prevention of colorectal cancer. Significant individual genetic variation exists in drug metabolism of 5FU, capecitabine, irinotecan, and oxaliplatin that influences both the toxicity and efficacy of these agents. Recent FDA approval of genetic testing for mutations in the UGT1A1 gene that predict adverse reactions to irinotecan is ushering in a new era that will increasingly rely on genotyping to individualize treatment decisions for patients with cancer as well as for patients at high risk who may be candidates for chemoprevention agents. This review focuses on current knowledge regarding key mutations and polymorphisms which affect outcomes for colorectal cancer patients, as well as the pharmacogenetics of chemoprevention trials.

publication date

  • October 1, 2006

Research

keywords

  • Antineoplastic Agents
  • Colorectal Neoplasms
  • Neoplasm Proteins
  • Pharmacogenetics

Identity

Scopus Document Identifier

  • 33748877201

Digital Object Identifier (DOI)

  • 10.1080/07357900600896281

PubMed ID

  • 16982469

Additional Document Info

volume

  • 24

issue

  • 6