Cancer-testis antigens: expression and correlation with survival in human urothelial carcinoma. Academic Article uri icon

Overview

abstract

  • PURPOSE: Vaccination against human cancer is a promising therapeutic approach but the optimal antigen or antigens remain undefined. Cancer-testis antigens (CTA), a family of tumor-associated antigens, have both potent immunogenicity and restricted expression patterns in normal adult tissues, highly desirable characteristics for targets of anticancer vaccines. These antigens were evaluated for both the degree of expression and prognostic value in cancer of the urothelium. EXPERIMENTAL DESIGN: The expression patterns of nine CTAs (NY-ESO-1, LAGE-1, MAGE-A1, MAGE-A3, MAGE-A4, MAGE-A10, CT7, CT10, and GAGE) were examined by immunohistochemistry and reverse transcription-PCR in a panel of high-grade urothelial carcinomas of the urinary bladder. Also assessed were correlations between the expression of CTAs by immunohistochemistry and both disease-free and overall survival. RESULTS: At least one CTA was expressed in 77% of samples and 61% of these tumors expressed more than one CTA. Additionally, patients with CT10-positive tumors had an improved disease-free survival (P=0.008) and overall survival (P=0.037) compared with patients with CT10-negative tumors. CONCLUSIONS: These findings establish CTAs as potential prognostic markers and as target candidates for vaccine development for patients with urothelial carcinoma.

publication date

  • September 15, 2006

Research

keywords

  • Antigens, Neoplasm
  • Testicular Neoplasms
  • Urologic Neoplasms

Identity

Scopus Document Identifier

  • 33749358027

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-06-0527

PubMed ID

  • 17000678

Additional Document Info

volume

  • 12

issue

  • 18