Ophthalmic cyclosporine use in ocular GVHD. Academic Article uri icon

Overview

abstract

  • PURPOSE: To evaluate the safety and efficacy of topical ophthalmic cyclosporine in patients with dry eyes secondary to graft-versus-host disease (GVHD). METHODS: Records of consecutive patients with ocular GVHD treated with topical cyclosporine were reviewed. RESULTS: Thirty-two eyes of 16 patients were included with a mean follow-up of 90 days. Dry eye symptoms improved in 10 patients (62.5%), and corneal fluorescein staining improved in all eyes (P = 0.0039). Global physician impression was favorable in 12 patients (75%). Ocular burning or irritation was noted in 3 patients (19%), which improved with either continuation of cyclosporine at the current dosing regimen or reduction in dose and/or concentration of cyclosporine. CONCLUSION: Ophthalmic cyclosporine seems to be safe and may be beneficial for patients with ocular GVHD, particularly those with more severe dry eyes.

publication date

  • July 1, 2006

Research

keywords

  • Cyclosporine
  • Dry Eye Syndromes
  • Graft vs Host Disease
  • Immunosuppressive Agents

Identity

Scopus Document Identifier

  • 33750561549

Digital Object Identifier (DOI)

  • 10.1097/01.ico.0000208818.47861.1d

PubMed ID

  • 17077652

Additional Document Info

volume

  • 25

issue

  • 6