Dynamics of dense electronegative low density lipoproteins and their preferential association with lipoprotein phospholipase A(2). Academic Article uri icon

Overview

abstract

  • Small, dense, electronegative low density lipoprotein [LDL(-)] is increased in patients with familial hypercholesterolemia and diabetes, populations at increased risk for coronary artery disease. It is present to a lesser extent in normolipidemic subjects. The mechanistic link between small, dense LDL(-) and atherogenesis is not known. To begin to address this, we studied the composition and dynamics of small, dense LDL(-) from normolipidemic subjects. NEFA levels, which correlate with triglyceride content, are quantitatively linked to LDL electronegativity. Oxidized LDL is not specific to small, dense LDL(-) or lipoprotein [a] (i.e., abnormal lipoprotein). Apolipoprotein C-III is excluded from the most abundant LDL (i.e., that of intermediate density: 1.034 < d < 1.050 g/ml) but associated with both small and large LDL(-). In contrast, lipoprotein-associated phospholipase A(2) (LpPLA(2)) is highly enriched only in small, dense LDL(-). The association of LpPLA(2) with LDL may occur through amphipathic helical domains that are displaced from the LDL surface by contraction of the neutral lipid core.

publication date

  • November 13, 2006

Research

keywords

  • Lipoproteins, LDL
  • Phospholipases A2

Identity

Scopus Document Identifier

  • 33846868176

Digital Object Identifier (DOI)

  • 10.1194/jlr.M600249-JLR200

PubMed ID

  • 17102149

Additional Document Info

volume

  • 48

issue

  • 2