Reversible attenuation of neuropathic-like manifestations in rats by lesions or local blocks of the intralaminar or the medial thalamic nuclei. Academic Article uri icon

Overview

abstract

  • BACKGROUND AND AIM: Thalamic somatosensory nuclei have been classified into medial and lateral systems based on their role in nociception. An imbalance between these two systems may result in abnormal somatic sensations and spontaneous pain. This study aims to investigate the effects of transient or permanent block of the medial and intralaminar nuclear groups on the neuropathic-like behavior in a rat model for mononeuropathy. METHODS: Neuropathy was induced on one hind paw in different groups of rats following the spared nerve injury model. When the resulting hyperalgesia and allodynia (tactile and cold) reached a maximum plateau, the rats received either chemical or electrolytic lesion or lidocaine (2%) microperfusion, placed in the various thalamic nuclear groups. RESULTS: All procedures produced transient but significant decrease of neuropathic manifestations. The magnitude and duration of decrease depended on the type and the site of the block. These effects can be ranked in increasing order as follows, electrolytic

publication date

  • November 28, 2006

Research

keywords

  • Denervation
  • Hyperalgesia
  • Hyperesthesia
  • Nerve Block
  • Peripheral Nerves
  • Thalamic Nuclei

Identity

Scopus Document Identifier

  • 33847290776

Digital Object Identifier (DOI)

  • 10.1016/j.expneurol.2006.10.009

PubMed ID

  • 17134698

Additional Document Info

volume

  • 204

issue

  • 1