EphA2 overexpression is associated with angiogenesis in ovarian cancer. Academic Article uri icon

Overview

abstract

  • BACKGROUND: EphA2 is overexpressed in the majority of ovarian cancers and predicts poor clinical outcome. Based on EphA2's emerging role in angiogenesis, we hypothesized that tumors overexpressing EphA2 demonstrate greater microvessel density (MVD) and matrix metalloproteinase (MMP) expression. METHODS: After Institutional Review Board (IRB) approval, 77 invasive epithelial ovarian tumors were analyzed for CD31, EphA2, MMP-2, MMP-9, and MT1-MMP expression. RESULTS: The median age of the patients was 59 years (range, 34-83). EphA2 was overexpressed in 76% of tumors and was associated with advanced-stage disease (P < .001) and high-grade histology (P = .04). MVD was stratified into high (>12.7 vessels/high-power field [HPF]) versus low (

publication date

  • January 15, 2007

Research

keywords

  • Neovascularization, Pathologic
  • Ovarian Neoplasms
  • Receptor, EphA2

Identity

Scopus Document Identifier

  • 33846212673

Digital Object Identifier (DOI)

  • 10.1002/cncr.22415

PubMed ID

  • 17154180

Additional Document Info

volume

  • 109

issue

  • 2