Modulation of adenoviral transduction in vitro and in vivo by hyaluronan and its receptor CD44. Academic Article uri icon

Overview

abstract

  • Adenovirus infection is a significant cause of ocular, respiratory, and gastrointestinal illness and can spread rapidly. Morbidity is considerable in immune-suppressed individuals and there is significant mortality. There are no effective therapies. During preclinical studies of adenoviral-mediated gene therapy for ocular disorders, we noticed a significant increase in transduction when the target cells were exposed to adenovirus in the presence of ocular vitreous. The vitreous is mainly comprised of water, collagen, and the large polysaccharide hyaluronan. In this paper, we report data that implicate hyaluronan in the adenoviral infectious process and show that interference with the interaction between hyaluronan and its cellular receptor CD44 can block adenovirus transduction in vitro and in vivo.

publication date

  • December 19, 2006

Research

keywords

  • Adenoviridae
  • Hyaluronan Receptors
  • Hyaluronic Acid
  • Transduction, Genetic

Identity

Scopus Document Identifier

  • 33847200462

Digital Object Identifier (DOI)

  • 10.1038/sj.mt.6300044

PubMed ID

  • 17180120

Additional Document Info

volume

  • 15

issue

  • 3