Ki-67 is an independent predictor of bladder cancer outcome in patients treated with radical cystectomy for organ-confined disease. Academic Article uri icon

Overview

abstract

  • PURPOSE: To determine the association of the cell proliferative marker Ki-67 with pathologic features and disease prognosis in patients with transitional cell carcinoma (TCC) of the urinary bladder. METHODS: Immunohistochemical staining for Ki-67 was done on serial cuts from tissue microarrays containing cystectomy specimens from 9 patients without bladder cancer and 226 consecutive patients with bladder TCC. We also assessed malignant lymph nodes from 50 of the 226 cystectomy patients. RESULTS: Ki-67 expression was increased in 42.5% cystectomy specimens and in 54% metastatic lymph nodes. In contrast, it was absent in all nine benign cystectomy specimens. Ki-67 overexpression was associated with advanced pathologic stage, higher grade, lymphovascular invasion, and metastases to lymph nodes (P = 0.001, 0.040, 0.031, and 0.036, respectively). In multivariate analyses, pathologic stage and lymph node metastases were independent predictors of disease recurrence and bladder cancer-specific mortality. In the subgroup of patients with organ-confined disease (

publication date

  • December 15, 2006

Research

keywords

  • Carcinoma, Transitional Cell
  • Ki-67 Antigen
  • Urinary Bladder Neoplasms

Identity

Scopus Document Identifier

  • 33846206414

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-06-1472

PubMed ID

  • 17189409

Additional Document Info

volume

  • 12

issue

  • 24