Outcomes in hepatitis C virus-infected recipients of living donor vs. deceased donor liver transplantation. Academic Article uri icon

Overview

abstract

  • In this retrospective study of hepatitis C virus (HCV)-infected transplant recipients in the 9-center Adult to Adult Living Donor Liver Transplantation Cohort Study, graft and patient survival and the development of advanced fibrosis were compared among 181 living donor liver transplant (LDLT) recipients and 94 deceased donor liver transplant (DDLT) recipients. Overall 3-year graft and patient survival were 68% and 74% in LDLT, and 80% and 82% in DDLT, respectively. Graft survival, but not patient survival, was significantly lower for LDLT compared to DDLT (P = 0.04 and P = 0.20, respectively). Further analyses demonstrated lower graft and patient survival among the first 20 LDLT cases at each center (LDLT 20; P = 0.002 and P = 0.002, respectively) and DDLT recipients (P < 0.001 and P = 0.008, respectively). Graft and patient survival in LDLT >20 and DDLT were not significantly different (P = 0.66 and P = 0.74, respectively). Overall, 3-year graft survival for DDLT, LDLT >20, and LDLT 20 were not significantly different. Important predictors of graft loss in HCV-infected patients were limited LDLT experience, pretransplant HCC, and higher MELD at transplantation.

publication date

  • January 1, 2007

Research

keywords

  • Hepacivirus
  • Hepatitis C
  • Liver Failure
  • Liver Transplantation
  • Living Donors
  • Tissue and Organ Procurement

Identity

PubMed Central ID

  • PMC3155862

Scopus Document Identifier

  • 33846232683

Digital Object Identifier (DOI)

  • 10.1002/lt.20995

PubMed ID

  • 17192908

Additional Document Info

volume

  • 13

issue

  • 1