PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors. Review uri icon

Overview

abstract

  • Molecularly targeted therapies are transforming the treatment of cancer. Elucidating the dynamic signaling networks that underlie sensitivity and resistance to these inhibitors is critical for successful clinical application. There is considerable evidence to suggest that constitutively activating mutations in kinases that regulate cellular growth may result in tumor cell "addiction" and favorable response to targeted inhibition. However, there is emerging evidence to suggest that clinical response may also be determined by other changes in the molecular circuitry of cancer cells, such as loss of key tumor-suppressor proteins. Here, we will discuss resistance to epidermal growth factor receptor tyrosine kinase inhibitors in glioblastoma patients that is mediated by loss of the PTEN tumor-suppressor protein.

publication date

  • January 15, 2007

Research

keywords

  • Brain Neoplasms
  • Enzyme Inhibitors
  • ErbB Receptors
  • Glioblastoma
  • PTEN Phosphohydrolase

Identity

Scopus Document Identifier

  • 33846852882

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-06-1992

PubMed ID

  • 17255257

Additional Document Info

volume

  • 13

issue

  • 2 Pt 1