Small round cell tumors of bone. Review uri icon

Overview

abstract

  • CONTEXT: Primary small round cell tumors of the bone are a heterogeneous group of malignant neoplasms presenting predominantly in children and adolescents. They include Ewing sarcoma/peripheral neuroectodermal tumor or Ewing family tumors, lymphoma, mesenchymal chondrosarcoma, and small cell osteosarcoma. Even though they share many morphological similarities, their unique biological and genetic characteristics have provided substantial insights into the pathology of these diverse neoplasms. OBJECTIVE: To provide an overview of the clinical, radiologic, pathologic, and genetic characteristics of these tumors along with a pertinent review of the literature. DATA SOURCES: A literature search using PubMed and Ovid MEDLINE was performed, and data were obtained from various articles pertaining to clinicopathologic, biological, and genetic findings in these tumors. Additionally, findings from rare cases have been included from author's subspecialty experience. CONCLUSION: The diagnosis of small round cell tumors can be made accurately by applying clinicopathologic criteria, as well as a panel of immunohistochemical and genetic studies in appropriate cases. Molecular genetic studies may provide further insight into the biology, histogenesis, and prognosis of these tumors.

publication date

  • February 1, 2007

Research

keywords

  • Bone Neoplasms

Identity

Scopus Document Identifier

  • 33846949677

Digital Object Identifier (DOI)

  • 10.5858/2007-131-192-SRCTOB

PubMed ID

  • 17284103

Additional Document Info

volume

  • 131

issue

  • 2