Event-related potentials in an emotional go/no-go task and remission of geriatric depression. Academic Article uri icon

Overview

abstract

  • Anterior cingulate integrity may be required for antidepressant response. To assess anterior cingulate processes related to treatment response, we studied error-related negativity and error positivity produced during an emotional go/no-go challenge, a task activating the rostral anterior cingulate. Twelve elderly patients with major depression, treated with escitalopram 10 mg daily, were studied. Patients who remained symptomatic after 8 weeks of treatment had larger error-related negativity and smaller error positivity amplitude compared with patients who achieved remission. The error-related negativity is elicited during conflict detection and the error positivity reflects the emotional reaction to error. Thus, these findings suggest that two distinct conflict-processing functions of the anterior cingulate are important for antidepressant response of geriatric depression.

publication date

  • February 12, 2007

Research

keywords

  • Aging
  • Antidepressive Agents
  • Depressive Disorder, Major
  • Emotions
  • Evoked Potentials
  • Gyrus Cinguli

Identity

Scopus Document Identifier

  • 33847175160

Digital Object Identifier (DOI)

  • 10.1097/WNR.0b013e328013ceda

PubMed ID

  • 17314660

Additional Document Info

volume

  • 18

issue

  • 3