Manipulation of early region 4. Review uri icon

Overview

abstract

  • Adenovirus early region 4 (E4) regulates processes in infected cells that include viral late gene expression, nonhomologous end joining, responses to DNA damage, and apoptosis. E4 is essential for viral growth in most cell lines. In this chapter, the current knowledge of the functions of six E4 products is summarized briefly. Protocols are presented for manipulation of E4, incorporation of E4 mutations into the viral genome, and growth of E4 mutants on complementing cell lines. A compilation of the described E4-complementing cell lines is included.

publication date

  • January 1, 2007

Research

keywords

  • Adenoviridae
  • Adenovirus E4 Proteins

Identity

Scopus Document Identifier

  • 34547455680

Digital Object Identifier (DOI)

  • 10.1385/1-59745-166-5:1

PubMed ID

  • 17401160

Additional Document Info

volume

  • 130