Metastatic renal cell carcinoma to hemangioblastoma in von Hippel-Lindau disease. uri icon

Overview

abstract

  • A case of metastatic renal cell carcinoma (RCC) to a capillary hemangioblastoma (HAB) of the central nervous system in a 52-year-old woman with von Hippel-Lindau (vHL) syndrome is described. We review the literature on metastatic RCC to HAB, summarize the histologic and immunohistochemical features that can distinguish between the 2 tumors, and comment on the significance of such a finding in terms of the clinical diagnosis of vHL. We found the expression of CAM 5.2, RCC antigen, and CD10 to be strong in RCC and absent in HAB and, conversely, staining with Leu-7, neural cell adhesion molecule, and inhibin-alpha was present in HAB but weak or absent in RCC. These antibodies can be used to differentiate these entities, provided one is astute in recognizing the possibility of their coexistence.

publication date

  • April 1, 2007

Research

keywords

  • Carcinoma, Renal Cell
  • Cerebellar Neoplasms
  • Hemangioblastoma
  • Kidney Neoplasms
  • Spinal Cord Neoplasms
  • von Hippel-Lindau Disease

Identity

Scopus Document Identifier

  • 34147125874

Digital Object Identifier (DOI)

  • 10.5858/2007-131-641-MRCCTH

PubMed ID

  • 17425399

Additional Document Info

volume

  • 131

issue

  • 4