FANCI is a second monoubiquitinated member of the Fanconi anemia pathway. Academic Article uri icon

Overview

abstract

  • Activation of the Fanconi anemia (FA) DNA damage-response pathway results in the monoubiquitination of FANCD2, which is regulated by the nuclear FA core ubiquitin ligase complex. A FANCD2 protein sequence-based homology search facilitated the discovery of FANCI, a second monoubiquitinated component of the FA pathway. Biallelic mutations in the gene coding for this protein were found in cells from four FA patients, including an FA-I reference cell line.

publication date

  • April 25, 2007

Research

keywords

  • DNA Repair
  • Fanconi Anemia
  • Fanconi Anemia Complementation Group Proteins

Identity

Scopus Document Identifier

  • 34249281152

Digital Object Identifier (DOI)

  • 10.1038/nsmb1252

PubMed ID

  • 17460694

Additional Document Info

volume

  • 14

issue

  • 6