Brain-derived neurotrophic factor: a newly described mediator of angiogenesis. Review uri icon

Overview

abstract

  • Recent studies indicate that, in addition to its neuropoietic actions, brain derived neurotrophic factor (BDNF) promotes endothelial cell survival and induces neoangiogenesis in ischemic tissues. Unlike many vascular growth factors that act on many vascular beds, BDNF activity is relatively restricted to central arteries, vessels of cardiac and skeletal muscle, and skin. Studies of newly described biologic mediators that act on large-vessel and microvascular beds in these organs will help us to better understand organ-specific vascular development, as well as to develop novel therapeutic strategies to improve the condition of patients with cardiac and peripheral vascular disease. In this review, we summarize dual proangiogenic actions of BDNF, which, through local activation of TrkB receptor, expressed on a subpopulation of endothelial cells and, in addition, by recruitment of bone marrow-derived cells, contribute to neoangiogenesis.

publication date

  • May 1, 2007

Research

keywords

  • Brain-Derived Neurotrophic Factor
  • Ischemia
  • Neovascularization, Pathologic

Identity

PubMed Central ID

  • PMC2268985

Scopus Document Identifier

  • 34247647524

Digital Object Identifier (DOI)

  • 10.1016/j.tcm.2007.03.002

PubMed ID

  • 17482097

Additional Document Info

volume

  • 17

issue

  • 4