Multiple drug resistance in osteogenic sarcoma: INT0133 from the Children's Oncology Group. Academic Article uri icon

Overview

abstract

  • PURPOSE: Multiple drug resistance due to P-glycoprotein (P-gp) expression has been reported to be a cause of disease recurrence in osteosarcoma. Tumor specimens derived from children and young adults with osteosarcoma enrolled onto a national Intergroup trial (INT0133) were analyzed prospectively to determine the role of multiple drug resistance in osteosarcoma. PATIENTS AND METHODS: From October 15, 1992, to November 25, 1997, 685 patients with localized, high-grade osteosarcoma were enrolled onto INT0133. Paraffin-embedded diagnostic tumor specimens were assayed for P-gp using monoclonal antibodies C-494 (139 patients) and JSB-1 (133 patients). Percent necrosis at the time of definitive surgery (NEC), event-free survival (EFS), and overall survival (OS) were evaluated as outcome measures for patients with P-gp-positive disease and were compared with patients with P-gp-negative disease. RESULTS: P-gp expression in the biopsy specimen did not significantly increase the risk for adverse outcomes as measured by EFS, OS, or NEC. EFS for those patients with C-494-positive tumors was 59% at 4 years versus 61% at 4 years for patients with C-494-negative tumors (P = .79), or 58% at 4 years versus 61% at 4 years for patients with JSB-1-positive versus JSB-1-negative tumors (P = .65). OS for patients with C-494-positive tumors was 82% at 4 years versus 82% at 4 years for patients with C-494-negative tumors (P = .61). CONCLUSION: Prospective analysis of the role of multiple drug resistance in localized osteosarcoma did not find that immunohistochemical analysis of P-gp expression predicted outcome for patients treated on INT0133.

publication date

  • May 20, 2007

Research

keywords

  • Antineoplastic Combined Chemotherapy Protocols
  • Bone Neoplasms
  • Drug Resistance, Multiple
  • Drug Resistance, Neoplasm
  • Osteosarcoma

Identity

Scopus Document Identifier

  • 34249936286

Digital Object Identifier (DOI)

  • 10.1200/JCO.2006.07.7776

PubMed ID

  • 17513810

Additional Document Info

volume

  • 25

issue

  • 15