Measures of energy balance and mammographic density in the Nurses' Health Study. Academic Article uri icon

Overview

abstract

  • Mammographic density is a strong risk factor for breast cancer; however the mechanism that underlies this association is unclear. We hypothesized that measures of energy balance early in life and in adulthood may be associated with mammographic density. We conducted a cross-sectional analysis of 1,398 women in the Nurses' Health Study to examine associations between physical activity, childhood and current body fatness, weight gain from age 18 years to present and mammographic density. Percent mammographic density was measured from digitized mammograms by a computer-assisted method. Demographic and lifestyle data were obtained from prospectively collected questionnaires. For all analyses, subjects were stratified into three groups: premenopausal women, postmenopausal women not currently taking hormones, and postmenopausal women currently taking hormones. Childhood body fatness was inversely associated with mammographic density. The correlations ranged from -0.15 to -0.19 in the three strata of women (P

publication date

  • June 26, 2007

Research

keywords

  • Breast Neoplasms
  • Mammography

Identity

Scopus Document Identifier

  • 42149159481

Digital Object Identifier (DOI)

  • 10.1007/s10549-007-9631-7

PubMed ID

  • 17592770

Additional Document Info

volume

  • 109

issue

  • 1