Clinically significant prostate cancer local recurrence after radiation therapy occurs at the site of primary tumor: magnetic resonance imaging and step-section pathology evidence. Academic Article uri icon

Overview

abstract

  • PURPOSE: To determine whether prostate cancer local recurrence after radiation therapy (RT) occurs at the site of primary tumor by retrospectively comparing the tumor location on pre-RT and post-RT magnetic resonance imaging (MRI) and using step-section pathology after salvage radical prostatectomy (SRP) as the reference standard. METHODS AND MATERIALS: Nine patients with localized prostate cancer were treated with intensity modulated RT (69-86.4 Gy), and had pre-RT and post-RT prostate MRI, biopsy-proven local recurrence, and SRP. The location and volume of lesions on pre-RT and post-RT MRI were correlated with step-section pathology findings. Tumor foci >0.2 cm(3) and/or resulting in extraprostatic disease on pathology were considered clinically significant. RESULTS: All nine significant tumor foci (one in each patient; volume range, 0.22-8.63 cm(3)) were detected both on pre-RT and post-RT MRI and displayed strikingly similar appearances on pre-RT and post-RT MRI and step-section pathology. Two clinically insignificant tumor foci (

publication date

  • September 1, 2007

Research

keywords

  • Magnetic Resonance Imaging
  • Neoplasm Recurrence, Local
  • Prostatic Neoplasms

Identity

Scopus Document Identifier

  • 34547850190

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2007.03.065

PubMed ID

  • 17707266

Additional Document Info

volume

  • 69

issue

  • 1