Targeting Cre recombinase to specific neuron populations with bacterial artificial chromosome constructs. Academic Article uri icon

Overview

abstract

  • Transgenic mouse lines are characterized with Cre recombinase driven by promoters of CNS-specific genes using bacterial artificial chromosome (BAC) constructs. BAC-Cre constructs for 10 genes (Chat, Th, Slc6a4, Slc6a2, Etv1, Ntsr1, Drd2, Drd1, Pcp2, and Cmtm5) produced 14 lines with Cre expression in specific neuronal and glial populations in the brain. These Cre driver lines add functional utility to the >500 BAC-EGFP (enhanced green fluorescent protein) transgenic mouse lines that are part of the Gene Expression Nervous System Atlas Project.

publication date

  • September 12, 2007

Research

keywords

  • Chromosomes, Artificial, Bacterial
  • Gene Targeting
  • Integrases
  • Neurons

Identity

PubMed Central ID

  • PMC6672645

Scopus Document Identifier

  • 34548651693

Digital Object Identifier (DOI)

  • 10.1523/JNEUROSCI.2707-07.2007

PubMed ID

  • 17855595

Additional Document Info

volume

  • 27

issue

  • 37