The yin and yang of intestinal epithelial cells in controlling dendritic cell function. Academic Article uri icon

Overview

abstract

  • Recent work suggests that dendritic cells (DCs) in mucosal tissues are "educated" by intestinal epithelial cells (IECs) to suppress inflammation and promote immunological tolerance. After attack by pathogenic microorganisms, however, "non-educated" DCs are recruited from nearby areas, such as the dome of Peyer's patches (PPs) and the blood, to initiate inflammation and the ensuing immune response to the invader. Differential epithelial cell (EC) responses to commensals and pathogens may control these two tolorogenic and immunogenic functions of DCs.

publication date

  • September 24, 2007

Research

keywords

  • Dendritic Cells
  • Epithelial Cells
  • Intestines
  • Yin-Yang

Identity

PubMed Central ID

  • PMC2118441

Scopus Document Identifier

  • 34948897919

Digital Object Identifier (DOI)

  • 10.1084/jem.20062535

PubMed ID

  • 17893197

Additional Document Info

volume

  • 204

issue

  • 10