Juvenile global tremor: a clinicopathologic syndrome mimicking polymyoclonia. uri icon

Overview

abstract

  • Olivary nucleus degeneration is one of the pathologic characteristics of infantile olivopontocerebellar atrophy. It has also been described in premature neonates and infants with severe perinatal asphyxia and is thought to represent retrograde transsynaptic changes from cerebellar hemisphere lesions. A 2-year-old boy developed global tremor after a respiratory infection with remission after corticosteroid therapy, and recurrence of the tremor during gradual withdrawal of steroids. Neuropathologic examination revealed neuronal loss and gliosis in the lateral portions of both inferior olivary nuclei without associated abnormalities in the cerebellum. This appears to be a unique case, both clinically and neuropathologically.

publication date

  • October 1, 2007

Research

keywords

  • Adrenal Cortex Hormones
  • Myoclonus
  • Respiratory Tract Infections
  • Tremor

Identity

Scopus Document Identifier

  • 34548838288

Digital Object Identifier (DOI)

  • 10.1016/j.pediatrneurol.2007.06.015

PubMed ID

  • 17903673

Additional Document Info

volume

  • 37

issue

  • 4