Protease-sensitive fluorescent nanofibers. Academic Article uri icon

Overview

abstract

  • We report the design and synthesis of enzyme-responsive nanofibers. The fibers are composed of self-assembled hydrophobic beta-sheet peptides incorporating protease-sensitive domains, fluorescent reporters, and hydrophilic poly(ethylene glycol) (PEG) units. Using urokinase plasminogen activator (uPA) as a model system, nanofibers were developed to release fluorescent fragments upon uPA incubation. These protease-sensitive nanofibers may have considerable biomedical applications as diagnostic sensors or for protease-assisted drug deliveries.

publication date

  • October 5, 2007

Research

keywords

  • Nanostructures
  • Urokinase-Type Plasminogen Activator

Identity

PubMed Central ID

  • PMC2528070

Scopus Document Identifier

  • 36849043984

Digital Object Identifier (DOI)

  • 10.1021/bc070054z

PubMed ID

  • 17915958

Additional Document Info

volume

  • 18

issue

  • 6