Early breast cancer therapy and cardiovascular injury. Review uri icon

Overview

abstract

  • Although recent advances in curative-intent therapies are beginning to produce significant survival gains in early breast cancer, these improvements may ultimately be attenuated by increased risk of long-term cardiovascular mortality. This paper reviews emerging evidence on the cardiovascular effects of breast cancer adjuvant therapy and proposes a new entity that we have labeled the "multiple-hit" hypothesis. The evidence that lifestyle modification, especially exercise therapy, may mitigate these adverse effects is also reviewed. These issues are of considerable practical importance for cardiovascular clinicians, as identification and intervention in those at high risk for cardiovascular complications may reduce a major cause of mortality in women with early breast cancer.

publication date

  • September 24, 2007

Research

keywords

  • Breast Neoplasms
  • Cardiovascular Diseases

Identity

Scopus Document Identifier

  • 34848877728

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2007.06.037

PubMed ID

  • 17919562

Additional Document Info

volume

  • 50

issue

  • 15