Brain, skull, and cerebrospinal fluid volumes in adult posttraumatic stress disorder. Academic Article uri icon

Overview

abstract

  • Children and adolescents with maltreatment-related posttraumatic stress disorder (PTSD) exhibit smaller intracranial tissue volume than controls. Linear relationships have also been observed between intracranial tissue volume and the age of maltreatment onset. The authors explored associations among adult PTSD, early trauma, and cerebral volumes in 99 combat veterans. A bone-based estimate of cranial volume was developed to adjust for variation in body size. Posttraumatic stress disorder was not associated with smaller cerebral tissue volume, but rather with smaller cerebrospinal fluid (CSF) and cranial volumes. These findings co-occurred with expected effects of alcoholism and aging on cerebral tissue and CSF volumes. The results point to early developmental divergences between groups with and without PTSD following adult trauma.

publication date

  • October 1, 2007

Research

keywords

  • Brain
  • Cerebrospinal Fluid
  • Skull
  • Stress Disorders, Post-Traumatic

Identity

Scopus Document Identifier

  • 36348967270

Digital Object Identifier (DOI)

  • 10.1002/jts.20241

PubMed ID

  • 17955544

Additional Document Info

volume

  • 20

issue

  • 5