Hepatitis B in pregnancy. Review uri icon

Overview

abstract

  • In countries with a high prevalence of chronic hepatitis B, perinatal transmission from mother to infant accounts for the majority of cases of chronic hepatitis B. Passive-active immunoprophylaxis with hepatitis B immunoglobulin and hepatitis B vaccine at birth is 95% efficacious in reducing the risk of HBV transmission but is less effective in HBeAg-positive mothers with very high serum HBV DNA levels. In the last 4 weeks of pregnancy lamivudine may provide additional protection in pregnant women who have high-level viremia. Further studies are needed to evaluate the use of nucleos(t)ide analogues to treat chronic hepatitis B during pregnancy.

publication date

  • November 1, 2007

Research

keywords

  • Hepatitis B virus
  • Hepatitis B, Chronic
  • Immunoglobulins
  • Infectious Disease Transmission, Vertical
  • Pregnancy Complications, Infectious

Identity

Scopus Document Identifier

  • 35548959064

Digital Object Identifier (DOI)

  • 10.1016/j.cld.2007.08.004

PubMed ID

  • 17981236

Additional Document Info

volume

  • 11

issue

  • 4