ESCRTing proteins in the endocytic pathway. Review uri icon

Overview

abstract

  • The endosomal sorting complex required for transport (ESCRT) machinery is highly conserved and its components have been found in all five major supergroups of eukaryotes. The three ESCRT complexes and associated proteins play critical roles in receptor downregulation, retroviral budding, and other normal and pathological cellular processes. Besides monoubiquitin-dependent protein cargo recognition and sorting, the ESCRT machinery also appears to drive the formation of multivesicular bodies (MVBs). Recent advances in the determination of the function and structure of the ESCRT complexes have improved our understanding of the molecular details underlying the assembly and regulation of the ESCRT machinery.

publication date

  • November 7, 2007

Research

keywords

  • Endocytosis
  • Protein Sorting Signals
  • Proteins

Identity

Scopus Document Identifier

  • 36248991778

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2007.09.010

PubMed ID

  • 17988873

Additional Document Info

volume

  • 32

issue

  • 12