HIV-1 pathogenesis: the complexities of the CCR5-CCL3L1 complex. Review uri icon

Overview

abstract

  • The chemokine receptor CCR5 is the most important entry coreceptor for HIV-1 in vivo. Its chemokine ligands, including CCL3L1, efficiently inhibit infection by receptor blockade and downmodulation. However, in Nature Immunology, Dolan et al. (2007) present a large human-cohorts study that identifies entry-independent, CCR5-CCL3L1-dependent effects on cell-mediated immunity as a strong correlate of pathogenesis and point to additional influences of the CCR5-CCL3L1 axis on disease progression through undefined mechanisms.

publication date

  • November 15, 2007

Research

keywords

  • Chemokines, CC
  • HIV Infections
  • HIV-1
  • Receptors, CCR5

Identity

Scopus Document Identifier

  • 35848947445

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2007.10.005

PubMed ID

  • 18005746

Additional Document Info

volume

  • 2

issue

  • 5