Degree of anticoagulation, but not warfarin use itself, predicts adverse outcomes after traumatic brain injury in elderly trauma patients. Academic Article uri icon

Overview

abstract

  • BACKGROUND: The relationship between preinjury warfarin use and outcomes after traumatic brain injury in elderly trauma patients remains controversial. We hypothesized that, among elderly warfarin users, the degree of anticoagulation, rather than warfarin therapy itself, would predict the severity of traumatic brain injury. METHODS: Retrospective study (2004-2006) of all elderly trauma patients (age >/=65 years) who were evaluated by the trauma service at a Level I trauma center and underwent computed tomography of the head for suspicion of an intracranial injury was performed. Three cohorts were grouped: (1) warfarin users with an admission International Normalized Ratio >/=2 (therapeutic group), (2) warfarin users with an admission International Normalized Ratio <2 (nontherapeutic group), and (3) warfarin nonusers. Main outcome variables were presenting with a Glasgow Coma Scale (GCS) score

publication date

  • September 1, 2007

Research

keywords

  • Anticoagulants
  • Brain Injuries
  • Intracranial Hemorrhages
  • Warfarin

Identity

Scopus Document Identifier

  • 38449121227

Digital Object Identifier (DOI)

  • 10.1097/TA.0b013e31812e5216

PubMed ID

  • 18073596

Additional Document Info

volume

  • 63

issue

  • 3