Immediate hypersensitivity elicits renin release from cardiac mast cells. Academic Article uri icon

Overview

abstract

  • BACKGROUND: We recently reported that murine and cavian heart mast cells are a unique extrarenal source of renin. Ischemia/reperfusion releases this renin leading to local angiotensin formation and norepinephrine release. As mast cells are a primary target of hypersensitivity, we assessed whether anaphylactic mast cell degranulation also results in renin and norepinephrine release. METHODS: Hearts isolated from presensitized guinea pigs were challenged with antigen. RESULTS: Cardiac anaphylaxis was characterized by mast cell degranulation, evidenced by beta-hexosaminidase release and associated with renin and norepinephrine release. Mast cell stabilization with cromolyn or lodoxamide markedly attenuated the release of beta-hexosaminidase, renin and norepinephrine. Renin inhibition with BILA2157 did not affect mast cell degranulation, but attenuated norepinephrine release. CONCLUSIONS: Our findings disclose that immediate-type hypersensitivity elicits renin release from mast cells, activating a local renin-angiotensin system, thereby promoting norepinephrine release. As renin is stored in human heart mast cells, allergic reactions could initiate renin release, leading to local angiotensin formation and hyperadrenergic dysfunction.

publication date

  • December 14, 2007

Research

keywords

  • Cell Degranulation
  • Hypersensitivity, Immediate
  • Mast Cells
  • Myocardium
  • Renin

Identity

Scopus Document Identifier

  • 42449098140

Digital Object Identifier (DOI)

  • 10.1159/000112505

PubMed ID

  • 18087164

Additional Document Info

volume

  • 146

issue

  • 1