The influence of long-term nifedipine or indomethacin therapy on neurologic recovery from experimental spinal cord injury. Academic Article uri icon

Overview

abstract

  • Inhibition of prostaglandin pathways and calcium channel conduction has been shown to improve neurological outcome after spinal cord injury. Functional recovery from such intervention has been routinely evaluated by a simple motor examination or somatosensory evoked potentials (SSEPs) after short-term drug administration. We comprehensively evaluated the influence of continuously administered indomethacin and nifedipine on functional outcome after impact spinal cord injury. SSEP and cortico-motor evoked potential records and neurologic examinations were obtained over 6 weeks after injury. Terminal histopathologic changes within the spinal cord were also examined. Only indomethacin significantly improved neurological function and reduced the severity of histopathologic change. Evoked potential analysis was not found to be of prognostic value. Modulation of prostaglandin pathways may enhance neurological recovery after spinal cord injury.

publication date

  • December 1, 1991

Research

keywords

  • Indomethacin
  • Nifedipine
  • Spinal Cord Injuries

Identity

Scopus Document Identifier

  • 0026351976

Digital Object Identifier (DOI)

  • 10.1097/00002517-199112000-00003

PubMed ID

  • 1810564

Additional Document Info

volume

  • 4

issue

  • 4