Clinical presentation and pathophysiology of EGFRI dermatologic toxicities. Review uri icon

Overview

abstract

  • This review summarizes the pathophysiology and clinical presentation of the cutaneous toxicities associated with EGFR inhibition. Such effects include papulopustular reactions, xerosis, pruritus, fissures, nail changes, hair changes, telangiectasias, hyperpigmentation, and mucositis. Most management strategies for these toxicities have been based on anecdotal experience; clinical trials are needed to provide uniform characterization to allow for evidence-based treatment strategies.

publication date

  • October 1, 2007

Research

keywords

  • Antineoplastic Agents
  • Drug Eruptions
  • ErbB Receptors
  • Protein Kinase Inhibitors

Identity

Scopus Document Identifier

  • 38549149740

PubMed ID

  • 18154212

Additional Document Info

volume

  • 21

issue

  • 11 Suppl 5