Self-assembled monolayer films of phosphonates for bonding RGD to titanium. Academic Article uri icon

Overview

abstract

  • Modification of the implant surface with the Arg-Gly-Asp tripeptide (RGD) putatively facilitates osteoblast attachment for improved implant fixation in the laboratory. We compared the histomorphometric and mechanical performance of titanium implants coated with RGD using a novel interface of self-assembled monolayers of phosphonates (RGD/SAMP) and implants coated with RGD using the more conventional thiolate-gold interface (RGD/thiolate-gold). We hypothesized RGD/SAMP-coated implants would show greater bone ongrowth and implant fixation than RGD/thiolate-gold-coated ones. We implanted an RGD/SAMP-coated implant in one femur and an RGD/thiolate-gold-coated in the contralateral femur of 60 rats. At 2, 4, and 8 weeks after implantation, 10 rats were sacrificed for histologic evaluation and another 10 for biomechanical testing. Bone-implant ongrowth and implant force-to-failure of the two implants were similar at all times. Although RGD/SAMP-coated implants did not show superior bone ongrowth and implant fixation, RGD/SAMP-coated implants have at least equally good histomorphometric and mechanical in vivo performance as RGD/thiolate-gold-coated ones. Additional in vivo characterization of self-assembled monolayer films of phosphonates as interface to bond RGD to titanium is needed to explore its full potential and seems justified based on the results of this study.

publication date

  • January 26, 2008

Research

keywords

  • Coated Materials, Biocompatible
  • Femur
  • Implants, Experimental
  • Oligopeptides
  • Organophosphonates
  • Osseointegration
  • Titanium

Identity

PubMed Central ID

  • PMC2504684

Scopus Document Identifier

  • 43349083322

Digital Object Identifier (DOI)

  • 10.1016/j.susc.2004.12.022

PubMed ID

  • 18224380

Additional Document Info

volume

  • 466

issue

  • 4