Targeting tissue angiotensin-converting enzyme for imaging cardiopulmonary fibrosis. Review uri icon

Overview

abstract

  • Convincing clinical and experimental evidence exists that the renin-angiotensin system and its primary effector peptide, angiotensin II, are linked to the pathophysiology of interstitial fibrosis in the heart and in the lung. Tissue angiotensin-converting enzyme and locally synthesized angiotensin II exert local trophic effects, which regulate fibroblast growth and proliferation. Thus, the presence of tissue renin-angiotensin system offers an opportunity for targeted imaging, which may be valuable for understanding the pathobiology of cardiopulmonary disorders and for guiding medical therapy.

publication date

  • March 1, 2008

Research

keywords

  • Angiotensin II
  • Angiotensin-Converting Enzyme Inhibitors
  • Heart
  • Myocardium
  • Peptidyl-Dipeptidase A
  • Pulmonary Fibrosis
  • Renin-Angiotensin System

Identity

Scopus Document Identifier

  • 44449165530

Digital Object Identifier (DOI)

  • 10.1007/s11886-008-0022-4

PubMed ID

  • 18417013

Additional Document Info

volume

  • 10

issue

  • 2