KRAS mutational testing in the selection of patients for EGFR-targeted therapies. Review uri icon

Overview

abstract

  • The small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors and the anti-EGFR monoclonal antibodies have proven activity in lung and colorectal adenocarcinomas, respectively, but only a small fraction of patients exhibit significant responses. The observation that only a minority of patients respond to EGFR-targeted therapies, in combination with their toxicity and high costs, has driven the search for molecular markers predictive of response. The main focus of the present review is the recent discovery that mutations in the KRAS oncogene constitute a negative predictive marker in this clinical setting, namely that their presence can be used to predict which patients are unlikely to benefit from treatment with EGFR-directed therapy.

publication date

  • November 1, 2008

Research

keywords

  • Adenocarcinoma
  • Drug Resistance, Neoplasm
  • ErbB Receptors
  • Proto-Oncogene Proteins
  • ras Proteins

Identity

Scopus Document Identifier

  • 53749106125

Digital Object Identifier (DOI)

  • 10.1053/j.semdp.2008.08.003

PubMed ID

  • 19013894

Additional Document Info

volume

  • 25

issue

  • 4