Signals arising from antigen-presenting cells. Review uri icon

Overview

abstract

  • It has been customary to consider that antigen-presenting cells provide, in addition to the presented antigen, a second or co-stimulatory signal that leads to T-cell growth and effector function. The recent literature indicates that this two-signal notion oversimplifies the function of antigen-presenting cells. Instead it is useful to consider four groups of events: the formation of peptide-MHC complexes, the role of soluble cytokines, the action of antigen-presenting cell-T cell molecular couples distinct from the receptor for peptide MHC, and the function of antigen-presenting cells in situ.

publication date

  • June 1, 1991

Research

keywords

  • Antigen-Presenting Cells
  • Signal Transduction

Identity

Scopus Document Identifier

  • 0025901107

Digital Object Identifier (DOI)

  • 10.1016/0952-7915(91)90039-4

PubMed ID

  • 1910616

Additional Document Info

volume

  • 3

issue

  • 3