Cell type-specific induction and inhibition of apoptosis by Herpes Simplex virus type 2 ICP10. Academic Article uri icon

Overview

abstract

  • Herpes simplex virus (HSV) inhibits apoptosis induced by external stimuli in epithelial cells. In contrast, apoptosis is the primary outcome in HSV-infected lymphocytes. Here, we show that HSV type 2 (HSV-2) gene expression appears to be necessary for the induction of apoptosis in Jurkat cells, a T-cell leukemia line. HSV-2 ICP10 gene expression is sufficient to induce apoptosis in Jurkat cells, while its expression protects epithelial HEp-2 cells from apoptosis triggered by cycloheximide and tumor necrosis factor alpha. Thus, the effect of HSV-2 gene expression on the cellular apoptotic pathway appears to depend on the specific cell type.

publication date

  • December 30, 2008

Research

keywords

  • Apoptosis
  • Herpesvirus 2, Human
  • Protein Serine-Threonine Kinases
  • Ribonucleotide Reductases

Identity

PubMed Central ID

  • PMC2648263

Scopus Document Identifier

  • 62749133514

Digital Object Identifier (DOI)

  • 10.1128/JVI.02088-08

PubMed ID

  • 19116254

Additional Document Info

volume

  • 83

issue

  • 6