Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism? Review uri icon

Overview

abstract

  • Basic fibroblast growth factor, (bFGF), promotes the formation of new blood capillaries and is sequestered and protected by binding to heparan sulfate (HS), both on the cell surface and in the extracellular matrix. Release of HS-bound bFGF by heparin-like molecules and HS-degrading enzymes (i.e., heparanase) provides a novel mechanism for regulation of the growth of capillary blood vessels in normal and pathological situations. The extracellular matrix also serves as a storage depot for other growth factors and enzymes.

publication date

  • July 1, 1991

Research

keywords

  • Extracellular Matrix
  • Fibroblast Growth Factor 2
  • Glucuronidase

Identity

Scopus Document Identifier

  • 0025812425

Digital Object Identifier (DOI)

  • 10.1016/0968-0004(91)90102-2

PubMed ID

  • 1926336

Additional Document Info

volume

  • 16

issue

  • 7