Splenic infarction and subsequent splenic rupture in a patient with paroxysmal nocturnal hemoglobinuria and heparin-induced thrombocytopenia. uri icon

Overview

abstract

  • We describe a patient with paroxysmal nocturnal hemoglobinuria (PNH) and no previous history of thrombosis who presented with hepatic venous thromboses and subsequently developed splenic infarction and rupture requiring splenectomy while on anticoagulation therapy for the hepatic thromboses. The patient's anticoagulation was complicated by heparin-induced thrombocytopenia (HIT) highlighting the unique management challenge presented by PNH in combination with HIT.

publication date

  • September 1, 2009

Research

keywords

  • Anticoagulants
  • Hemoglobinuria, Paroxysmal
  • Heparin
  • Splenic Infarction
  • Splenic Rupture
  • Thrombocytopenia

Identity

Scopus Document Identifier

  • 67651236095

Digital Object Identifier (DOI)

  • 10.1002/pbc.22058

PubMed ID

  • 19415735

Additional Document Info

volume

  • 53

issue

  • 3