HIV-1-specific T Cell-dependent natural killer (NK) cell activation: major contribution by NK cells to interferon-gamma production in response to HIV-1 antigens. Academic Article uri icon

Overview

abstract

  • Natural killer (NK) cells can directly recognize virus-infected cells. Here, we demonstrate that NK cells also produce interferon (IFN)-gamma in an HIV-1-specific, T cell-dependent manner. After stimulation of peripheral blood mononuclear cells (PBMCs) from HIV-1-infected individuals with HIV-1-derived peptides, up to half of the IFN-gamma-producing PBMCs are NK cells. These results indicate that T cell-dependent NK cell IFN-gamma production can be important for immune control of HIV-1, and have implications for the interpretation of data from vaccine trials using ELISPOT and ELISA.

publication date

  • June 1, 2009

Research

keywords

  • HIV Antigens
  • HIV Infections
  • HIV-1
  • Interferon-gamma
  • Killer Cells, Natural
  • T-Lymphocytes

Identity

PubMed Central ID

  • PMC2853859

Scopus Document Identifier

  • 67651148089

Digital Object Identifier (DOI)

  • 10.1089/aid.2008.0165

PubMed ID

  • 19500013

Additional Document Info

volume

  • 25

issue

  • 6