4'-EPI-doxorubicin in advanced lung cancer. A phase II trial. Academic Article uri icon

Overview

abstract

  • Fifty evaluable patients with advanced lung cancer (28 small cell and 22 non-small cell carcinomas), mainly pretreated by chemotherapy, received 4'-epi-doxorubicin 90 mg/m2 every 3 weeks. Two partial responses were obtained in small cell lung cancer patients, which lasted 153 and 168 days. Leukopenia, emesis and alopecia were the most frequent side effects. Two patients who previously received anthracyclines died suddenly of cardiac failure, another patient had severe congestive heart failure, and four others had minor cardiac dysfunctions. 4'-epi-doxorubicin has a modest activity in advanced lung cancer, mainly pretreated by chemotherapy and is not devoid of significant cardiotoxicity in this patient population.

publication date

  • November 1, 1990

Research

keywords

  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Small Cell
  • Drugs, Investigational
  • Epirubicin
  • Lung Neoplasms

Identity

Scopus Document Identifier

  • 0025184066

Digital Object Identifier (DOI)

  • 10.1007/BF00198599

PubMed ID

  • 1964677

Additional Document Info

volume

  • 8

issue

  • 4