Induction of high-titer neutralizing antibodies, using hybrid human immunodeficiency virus V3-Ty viruslike particles in a clinically relevant adjuvant. Academic Article uri icon

Overview

abstract

  • The localization of neutralization determinants within the envelope glycoproteins of human immunodeficiency virus (HIV) has been largely achieved by immunizing small animals in conjunction with Freund's adjuvant. However, for eventual use in humans, candidate HIV vaccine components must also be efficacious in a nontoxic formulation. We describe here the production of hybrid Ty viruslike particles carrying the major neutralizing domain of HIV and demonstrate the induction of high-titer virus-neutralizing antibodies and an HIV-specific T-cell proliferative response after immunization in conjunction with aluminum hydroxide. As aluminum hydroxide and aluminum phosphate are the only adjuvants currently licensed for use in humans, these observations have implications for the development of an effective vaccine against HIV.

publication date

  • January 1, 1991

Research

keywords

  • Antibodies, Monoclonal
  • HIV
  • HIV Antibodies
  • HIV Envelope Protein gp120

Identity

PubMed Central ID

  • PMC240536

Scopus Document Identifier

  • 0025964642

Digital Object Identifier (DOI)

  • 10.1128/JVI.65.1.450-456.1991

PubMed ID

  • 1985208

Additional Document Info

volume

  • 65

issue

  • 1