Notch regulates the angiogenic response via induction of VEGFR-1. Academic Article uri icon

Overview

abstract

  • Notch is a critical regulator of angiogenesis and arterial specification. We show that ectopic expression of activated Notch1 induces endothelial morphogenesis in human umbilical vein endothelial cells (HUVEC) in a VEGFR-1-dependent manner. Notch1-mediated upregulation of VEGFR-1 in HUVEC increased their responsiveness to the VEGFR-1 specific ligand, Placental Growth Factor (PlGF). In mice and human endothelial cells, inhibition of Notch signaling resulted in decreased VEGFR-1 expression during VEGF-A-induced neovascularization. In summary, we show that Notch1 plays a role in endothelial cells by regulating VEGFR-1, a function that may be important for physiological and pathological angiogenesis.

publication date

  • January 26, 2010

Identity

PubMed Central ID

  • PMC2828996

Scopus Document Identifier

  • 28644432204

Digital Object Identifier (DOI)

  • 10.1038/nature04186

PubMed ID

  • 20298529

Additional Document Info

volume

  • 2

issue

  • 1