Three-dimensional photon treatment planning for Hodgkin's disease. Academic Article uri icon

Overview

abstract

  • A multi-institutional study was undertaken using computerized planning systems to develop three-dimensional (3-D) radiotherapy plans for Hodgkin's disease (H.D.). Two patients, the first afflicted with bulky stage II disease and another one with early stage I H.D., were studied. Three main categories of plan were produced for each patient: a) a traditional plan which modelled a conventional mantle treatment on the 3-D system, b) a 3-D standard plan where anterior and posterior fields were designed to cover 3-D target volumes, and c) a 3-D unconstrained plan where innovational techniques were employed. Three-dimensional planning provides information about the dose distribution throughout the large volume irradiated in patients with H.D. that is not available with conventional mantle planning. The use of 3-D techniques resulted in improved tumor coverage, but by allowing for uncertainties such as motion, the doses to normal tissues tended to be higher. The use of unorthodox beam arrangements introduced added complexities, and further increased the lung doses. The most even dose distributions were obtained by incorporating compensating filters into anterior fields. Clinicians showed wide variations in their assessment of the plans, possible reasons for which are addressed in this paper. In addition, calculated probabilities from models of tumor control and normal tissue damage are also presented.

publication date

  • May 15, 1991

Research

keywords

  • Hodgkin Disease
  • Radiotherapy Planning, Computer-Assisted

Identity

Scopus Document Identifier

  • 0026058919

Digital Object Identifier (DOI)

  • 10.1016/0360-3016(91)90179-8

PubMed ID

  • 2032889

Additional Document Info

volume

  • 21

issue

  • 1