Early decreased tumor volume following fractionated Gamma Knife Radiosurgery for metastatic melanoma and the role of "adaptive radiosurgery": case report. uri icon

Overview

abstract

  • OBJECTIVE: We report a case in which fractionated gamma knife radiosurgery was used to treat a metastatic melanoma lesion. The tumor demonstrated a rapid response to radiosurgery with an observable reduction in tumor volume between the second and third treatments, requiring a favorable modification in the third fractionated treatment. CLINICAL PRESENTATION: A 61-year-old woman presented with a frontal floor metastatic melanoma lesion that was located adjacent to the optic apparatus. INTERVENTION: Gamma knife radiosurgery was administered in three fractionated treatments of 6.5 Gy to the 50% isodose line in each case. Repeat imaging for the purpose of planning demonstrated that tumor volume at the time of the third treatment, 9 days following the first treatment, had decreased by 31%, resulting in a 21% decrease in the dose administered to the optic chiasm. CONCLUSION: A case of metastatic melanoma treated with fractionated GKRS is presented, in which a significant reduction in tumor volume was noted 9 days following the initial treatment. This case provides insight into the rate with which malignant neoplasms may respond to intermediate-dose hypofractionated GKRS, and lends support to the concept of "adaptive radiosurgery" as a means of optimizing radiation to an evolving target while minimizing collateral radiation to surrounding structures.

publication date

  • August 1, 2010

Research

keywords

  • Brain Neoplasms
  • Melanoma
  • Radiosurgery

Identity

Scopus Document Identifier

  • 77954984543

Digital Object Identifier (DOI)

  • 10.1227/01.NEU.0000371984.18490.55

PubMed ID

  • 20644382

Additional Document Info

volume

  • 67

issue

  • 2