FDG PET in the Evaluation of Parkinson's Disease. Academic Article uri icon

Overview

abstract

  • Network analysis of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is an innovative approach for the study of in movement disorders, such as Parkinson's disease (PD). Spatial covariance analysis of imaging data acquired from PD patients has revealed characteristic regional patterns associated with the motor and cognitive features of disease. Quantification of pattern expression in individual patients can be used for diagnosis, assessment of disease severity, and evaluation of novel medical and surgical therapies. Identification of disease-specific patterns in other parkinsonian syndromes, such as multiple system atrophy and progressive supranuclear palsy, has improved diagnostic accuracy in patients with difficult to diagnose parkinsonism. Further developments of these techniques are likely to enhance the role of functional imaging in investigating underlying abnormalities and potential new therapies in these neurodegenerative diseases.

publication date

  • January 1, 2010

Identity

PubMed Central ID

  • PMC2913894

Scopus Document Identifier

  • 77956625269

Digital Object Identifier (DOI)

  • 10.1016/j.cpet.2009.12.004

PubMed ID

  • 20689674

Additional Document Info

volume

  • 5

issue

  • 1