Early developmental regression in autism spectrum disorder: evidence from an international multiplex sample. Academic Article uri icon

Overview

abstract

  • The characteristics of early developmental regression (EDR) were investigated in individuals with ASD from affected relative pairs recruited to the International Molecular Genetic Study of Autism Consortium (IMGSAC). Four hundred and fifty-eight individuals with ASD were recruited from 226 IMGSAC families. Regression before age 36 months occurred in 23.9% of individuals. The observed concordance rate for EDR within sibling pairs (18.9%) was not significantly above the rate expected under independence (13.5%, p = 0.10). The rate of regression in individuals with ASD from multiplex families was similar to that reported in singleton and epidemiological samples. Regression concordance data were not supportive of a separate familial influence on EDR, other than as a part of autism itself.

authors

  • Lord, Catherine
  • Parr, Jeremy R
  • Le Couteur, Ann
  • Baird, Gillian
  • Rutter, Michael
  • Pickles, Andrew
  • Fombonne, Eric
  • Bailey, Anthony J

publication date

  • March 1, 2011

Research

keywords

  • Child Development
  • Child Development Disorders, Pervasive
  • Language Development
  • Regression, Psychology

Identity

Scopus Document Identifier

  • 79956035163

Digital Object Identifier (DOI)

  • 10.1007/s10803-010-1055-2

PubMed ID

  • 20711649

Additional Document Info

volume

  • 41

issue

  • 3