Defective expression of high affinity IL-2 receptors on activated T cells from aged humans. Academic Article uri icon

Overview

abstract

  • The proliferative response of T cells from aged humans to a number of mitogens is significantly reduced. We report here that there is a decrease in high affinity IL-2 receptor (IL-2R) expression on activated T cells from aged humans. Scatchard analysis of the binding of [125I]IL-2 demonstrates fewer high affinity IL-2 binding sites. Autoradiographic techniques demonstrate that this results from there being fewer activated T cells from old as compared to young donors that express high affinity IL-2R. However, T cells from old donors that do not express high affinity IL-2 binding sites express both the IL-2 binding 55 and 75 kd chains. Thus, although the two IL-2 binding peptides are expressed on activated T cells from old donors, expression of the high affinity IL-2R is reduced. This may explain the decreased ability of T cells from old donors to respond to IL-2. The impaired ability of activated T cells from old donors to express high affinity IL-2R while expressing the 55 and 75 kd chains may provide insights into the mechanisms of IL-2 interactions with its receptor.

publication date

  • January 1, 1990

Research

keywords

  • Aging
  • Receptors, Interleukin-2
  • T-Lymphocytes

Identity

Scopus Document Identifier

  • 0025271565

Digital Object Identifier (DOI)

  • 10.1093/intimm/2.3.239

PubMed ID

  • 2088488

Additional Document Info

volume

  • 2

issue

  • 3