Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. Review uri icon

Overview

abstract

  • A multicenter meta-analysis including data from 9,389 psoriasis patients and 9,477 control subjects was performed to investigate the contribution of the deletion of genes LCE3C and LCE3B, involved in skin barrier defense, to psoriasis susceptibility in different populations. The study confirms that the deletion of LCE3C and LCE3B is a common genetic factor for susceptibility to psoriasis in the European populations (OR(Overall) = 1.21 (1.15-1.27)), and for the first time directly demonstrates the deletion's association with psoriasis in the Chinese (OR = 1.27 (1.16-1.34)) and Mongolian (OR = 2.08 (1.44-2.99)) populations. The analysis of the HLA-Cw6 locus showed significant differences in the epistatic interaction with the LCE3C and LCE3B deletion in at least some European populations, indicating epistatic effects between these two major genetic contributors to psoriasis. The study highlights the value of examining genetic risk factors in multiple populations to identify genetic interactions, and indicates the need of further studies to understand the interaction of the skin barrier and the immune system in susceptibility to psoriasis.

authors

  • Riveira-Munoz, Eva
  • He, Su-Min
  • Escaramís, Georgia
  • Stuart, Philip E
  • Hüffmeier, Ulrike
  • Lee, Catherine
  • Kirby, Brian James
  • Oka, Akira
  • Giardina, Emiliano
  • Liao, Wilson
  • Bergboer, Judith
  • Kainu, Kati
  • de Cid, Rafael
  • Munkhbat, Batmunkh
  • Zeeuwen, Patrick L J M
  • Armour, John A L
  • Poon, Annie
  • Mabuchi, Tomotaka
  • Ozawa, Akira
  • Zawirska, Agnieszka
  • Burden, A David
  • Barker, Jonathan N
  • Capon, Francesca
  • Traupe, Heiko
  • Sun, Liang-Dan
  • Cui, Yong
  • Yin, Xian-Yong
  • Chen, Gang
  • Lim, Henry W
  • Nair, Rajan P
  • Voorhees, John J
  • Tejasvi, Trilokraj
  • Pujol, Ramón
  • Munkhtuvshin, Namid
  • Fischer, Judith
  • Kere, Juha
  • Schalkwijk, Joost
  • Bowcock, Anne
  • Kwok, Pui-Yan
  • Novelli, Giuseppe
  • Inoko, Hidetoshi
  • Ryan, Anthony W
  • Trembath, Richard C
  • Reis, André
  • Zhang, Xue-Jun
  • Elder, James T
  • Estivill, Xavier

publication date

  • November 25, 2010

Research

keywords

  • Cornified Envelope Proline-Rich Proteins
  • Gene Deletion
  • HLA-C Antigens
  • Psoriasis

Identity

PubMed Central ID

  • PMC3386316

Scopus Document Identifier

  • 79953129971

Digital Object Identifier (DOI)

  • 10.1038/jid.2010.350

PubMed ID

  • 21107349

Additional Document Info

volume

  • 131

issue

  • 5